Exposure to Inhalational Anaesthetics Causes Neuroinflammation

Biotransformation and toxicity of inhalational anaesthetics.

In summary, anaesthetics and drugs used perioperatively are all xenobiotics and can be metabolized mainly by microsomal enzyme systems, which have a high activity in the liver. These enzyme systems are induced by repeated pre-administration of drugs, such as barbiturates and others which are used during the preoperative period. However, according to some reports, aerobic and anaerobic metabolis...

Nephrotoxicity of halogenated inhalational anaesthetics: fictions and facts.

Neuropsychological symptoms and occupational exposure to anaesthetics.

OBJECTIVE To analyse the relation between symptoms regularly reported by hospital personnel and exposure to anaesthetics. SETTING Personnel of 18 hospitals in Paris from 1987 to 1989. DESIGN An exposed group that included all operating theatre members except for doctors, and which was divided into three subgroups depending on the degree of exposure--exposure was measured by the frequency of...

Lifetime behavioural changes after exposure to anaesthetics in infant rats

The aim of this study was to assess the effect of acute use of general anaesthetic with or without a surgical procedure, at post-natal day 14 (P14), on behavioural responses in the short-, medium- and long-term, evaluated in open field (OF) and elevated plus-maze (EPM) tests. Fourteen-day-old male Wistar rats were divided into two experimental designs (ED): inhalation and intravenous anaestheti...

Measurement and reduction of occupational exposure to inhaled anaesthetics.

The occupational exposure of hospital staff to inhaled anaesthetics was investigated using a personal sampling device that provides a measure of the average concentrations breathed by a person over a period of time, as distinct from the spot sampling in the general environment. The anaesthetist's average exposure to nitrous oxide and halothane during complete operating sessions was twice that e...